I-131 MIBG Therapy for Advanced Stage III & IV Neuroblastoma
نویسندگان
چکیده
منابع مشابه
I-131 MIBG Therapy for Advanced Stage III & IV Neuroblastoma
Radio-labelled MIBG therapy has been tried in the treatment of advanced stage III and IV neuroblastoma in an attempt to improve patients outcome. The use of radiolabelled MIBG to treat neuroblastoma has arisen from the high sensitivity and specificity of in vivo MIBG imaging for detection of primary and metastatic tumours. Although, clinical trials have been performed to determine the role of M...
متن کاملRole of 131-I MIBG Therapy in the Treatment of Advanced Neuroblastoma.
INTRODUCTION Neuroblastoma, a neoplasm of the sympathetic nervous system, is the second most extracranial malignant solid tumor of childhood. Many therapeutic strategies has evolved over the last 20 years, based upon work by international cooperative groups and smaller cohort studies. Novel therapies to improve initial disease response and treatment of minimal residual disease are required to i...
متن کاملDoes I-131-MIBG underestimate skeletal disease burden in neuroblastoma?
BACKGROUND Controversy persists as to the need for both MIBG and bone scanning in routine evaluation of neuroblastoma. AIM To compare the efficacy of I-131- metaiodobenzylguanidine (MIBG) scan against that of conventional Tc99m- methylene diphosphonate (MDP) bone scan for the detection of skeletal deposition of neuroblastoma. METHODS AND MATERIAL The study included 57 patients (36 boys, 21 ...
متن کاملدرمان تومورهای غددی-عصبی با I-131 Metaiodobenzylguanidine (I-131 MIBG)
زمینه: کاربرد رادیودارویI-131 MIBG در درمان تومورهای با منشأ غددی- عصبی، خصوصاً از نوع نورواکتودرمال (سمپاتوآدرنال) شامل فئوکروموسیتوم، پاراگانگلیوم و نوروبلاستوم مؤثر بوده است. در سایر تومورهای غددی- عصبی (عمدتاً کارسینوئید و کارسینوم مدولاری تیروئید) نیز این درمان گاهی می‌تواند مؤثر واقع گردد. مواد و روش‌ها: در این مطالعه مروری، کارآزمایی‌های بالینی شاهد - موردی و همچنین مطالعات باز که دارای اع...
متن کاملBiodistribution of post-therapeutic versus diagnostic (131)I-MIBG scans in children with neuroblastoma.
BACKGROUND To evaluate the biodistribution of therapeutic (131)I-metaiodobenzylguanidine (MIBG) and assess the sensitivity of diagnostic versus therapeutic (131)I-MIBG scans to detect metastatic disease. PROCEDURE This retrospective study included 44 diagnostic and post-therapy scans (PTS) in 18 children with neuroblastoma treated with (131)I-MIBG (2.0-33.1 GBq). The findings of diagnostic sc...
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ژورنال
عنوان ژورنال: Journal of Cancer Therapy
سال: 2011
ISSN: 2151-1934,2151-1942
DOI: 10.4236/jct.2011.24065